Literature summary for 1.1.1.86 extracted from

Liu, X.H.; Chen, P.Q.; Wang, B.L.; Dong, W.L.; Li, Y.H.; Xie, X.Q.; Li, Z.M.
High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors (2010), Chem. Biol. Drug Des., 75, 228-232.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-carbamoylcyclopropanecarboxylic acid	-	Oryza sativa
1-cyanocyclopropanecarboxylic acid	-	Oryza sativa
cyclopropane-1,1-dicarboxylic acid	-	Oryza sativa
additional information	high throughput receptor-based virtual screening of the ZINC/drug like database based on the crystal structure of ketol-acid reductoisomerase/N-hydroxy-N-isopropyloxamate complex, PDB entry 1YVE	Oryza sativa
N-Hydroxy-N-isopropyloxamate	-	Oryza sativa

Organism

Organism	UniProt	Comment	Textmining
Oryza sativa	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0027	-	N-Hydroxy-N-isopropyloxamate	pH 8.0, 30°C	Oryza sativa
0.031	-	1-carbamoylcyclopropanecarboxylic acid	pH 8.0, 30°C	Oryza sativa
0.076	-	cyclopropane-1,1-dicarboxylic acid	pH 8.0, 30°C	Oryza sativa
0.095	-	1-cyanocyclopropanecarboxylic acid	pH 8.0, 30°C	Oryza sativa

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Release 2023.1 (January 2023)