Literature summary for 1.1.1.85 extracted from

He, Y.; Chen, L.; Zhou, Y.; Mawhinney, T.; Chen, B.; Kang, B.; Hauser, B.; Chen, S.
Functional characterization of Arabidopsis thaliana isopropylmalate dehydrogenases reveals their important roles in gametophyte development (2011), New Phytol., 189, 160-175.

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Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	P93832	isoform IPMDH2	-
Arabidopsis thaliana	Q9FMT1	isoform IPMDH3	-

General Information

General Information	Comment	Organism
physiological function	isoforms IPMDH2 and IPMDH3 proteins exhibit significantly higher activity toward 3-isopropylmalate than isoform IPMDH1. Single mutants of isoforms IPMDH2 or IPMDH3 lack a discernible phenotype. A ipmdh2 ipmdh3 double mutant is lethal in male gametophytes and has reduced transmission through female gametophytes. The aborted pollen grains are small, abnormal in cellular structure, and arrested in germination. Half of the double mutant embryo sacs exhibits slowed development. The IPMDH2/ipmdh2 ipmdh3/ipmdh3 genotype exhibits abnormal vegetative phenotypes. This mutant and a triple mutant containing one allele of IPMDH2 or IPMDH3 have decreased leucine biosynthetic enzyme activities and lower free leucine concentrations	Arabidopsis thaliana

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Release 2023.1 (January 2023)