Literature summary for 1.1.1.85 extracted from

Singh, R.K.; Kefala, G.; Janowski, R.; Mueller-Dieckmann, C.; von Kries, J.P.; Weiss, M.S.
The High-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis (2005), J. Mol. Biol., 346, 1-11.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
The crystal structure is determined at 1.65 A resolution. The crystals contain two functional dimers in the asymmetric unit in an arrangement close to a tetramer of D2 symmetry.	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
O-isobutenyloxalylhydroxamate	O-isobutenyloxalylhydroxamate binds to the active site of enzyme in a mode similar to the substrate isopropylmalate	Mycobacterium tuberculosis

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Mycobacterium tuberculosis
Mn2+	required	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WKK9	-	-
Mycobacterium tuberculosis H37Rv	P9WKK9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2R,3S)-3-isopropylmalate + NAD+	-	Mycobacterium tuberculosis	2-isopropyl-3-oxosuccinate + NADH + H+	-	r
(2R,3S)-3-isopropylmalate + NAD+	-	Mycobacterium tuberculosis H37Rv	2-isopropyl-3-oxosuccinate + NADH + H+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Mycobacterium tuberculosis
NADH	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)