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Literature summary for 1.1.1.82 extracted from

  • Beeler, S.; Liu, H.C.; Stadler, M.; Schreier, T.; Eicke, S.; Lue, W.L.; Truernit, E.; Zeeman, S.C.; Chen, J.; Koetting, O.
    Plastidial NAD-dependent malate dehydrogenase is critical for embryo development and heterotrophic metabolism in Arabidopsis (2014), Plant Physiol., 164, 1175-1190.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.82

Activating Compound

Activating Compound Comment Organism Structure
light NADP-MDH is a strictly redox-regulated, light-activated enzyme that is inactive in the dark Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
oxaloacetate + NADPH + H+ Arabidopsis thaliana
-
 (S)-malate + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8H1E2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oxaloacetate + NADPH + H+
-
 Arabidopsis thaliana (S)-malate + NADP+
-
 r

Synonyms

Synonyms Comment Organism
MDH
-
 Arabidopsis thaliana
NADP-dependent malate dehydrogenase
-
 Arabidopsis thaliana
NADP-MDH
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Arabidopsis thaliana
NADPH
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function in illuminated chloroplasts, one mechanism involved in reduction oxidation (redox) homeostasis is the malate-oxaloacetate shuttle. Excess electrons from photosynthetic electron transport in the form of nicotinamide adenine dinucleotide phosphate, reduced are used by NADP+-dependent malate dehydrogenase to reduce oxaloacetate to malate, thus regenerating the electron acceptor NADP+. Since NADP-MDH is a strictly redox-regulated, light-activated enzyme that is inactive in the dark, the malate-oxaloacetate shuttle is in the dark or in nonphotosynthetic tissues proposed to be mediated by the constitutively active plastidial NAD-specific MDH isoform (pdNAD-MDH, EC 1.1.1.37), which is is active under both light and dark conditions. pdNAD-MDH deficiency in miR-mdh-1 can be functionally complemented by expression of a microRNA-insensitive pdNAD-MDH but not NADP-MDH, confirming distinct roles for NAD- and NADP-linked redox homeostasis. NADP-MDH is not crucial for providing electron acceptors in chloroplasts Arabidopsis thaliana