Literature summary for 1.1.1.8 extracted from

Zhou, C.; Yu, J.; Wang, M.; Yang, J.; Xiong, H.; Huang, H.; Wu, D.; Hu, S.; Wang, Y.; Chen, X.Z.; Tang, J.
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer (2017), Oncotarget, 8, 101309 .

Search for more literature for 1.1.1.8

Application

Application	Comment	Organism
medicine	the mRNA expression level of glycerol-3-phosphate dehydrogenase (GPD1) is significantly downregulated in human breast cancer patients. Patients with reduced GPD1 expression exhibit poorer overall metastatic relapse-free survival. The reduced expression of GPD1 is an independent predictor of overall survival in oestrogen receptor-positive and nodal-negative breast cancer patients. GPD1 is a direct target of miR-370, which is significantly upregulated in human breast cancer. Exogenous expression of GPD1 in MCF-7 and MDA-MB-231 breast cancer cells significantly inhibits cell proliferation, migration, and invasion	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21695	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	exogenous expression of GPD1 in human MCF-7 and MDA-MB-231 breast cancer cells significantly inhibits cell proliferation, migration, and invasion	Homo sapiens

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Release 2023.1 (January 2023)