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Literature summary for 1.1.1.8 extracted from

  • Rauchova, H.; Mracek, T.; Novak, P.; Vokurkova, M.; Soukup, T.
    Glycerol-3-phosphate dehydrogenase expression and oxygen consumption in liver mitochondria of female and male rats with chronic alteration of thyroid status (2011), Horm. Metab. Res., 43, 43-47.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the hypothyroid status to a significant increase of both enzyme amount and activity in both female and male animals Rattus norvegicus

Application

Application Comment Organism
medicine the hyperthyroid status leads to a significant decrease and the hypothyroid status to a significant increase of both enzyme amount and activity in both female and male animals. The euthyroid and hyperthyroid females show a higher activity and the hyperthyroid females also show a higher enzyme amount in comparison with male animals, while the hypothyroid animals show low levels in both sexes. The enzyme-dependent oxygen consumption of freshly isolated liver mitochondria from hyperthyroid animals is higher compared with euthyroid animals, and is activated bycoenzyme Q analogue idebenone, in both euthyroid and hyperthyroid rats. Determination of enzyme amount and activity can serve as an additional criterion for the evaluation of the thyroid hormone status Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information the hyperthyroid status leads to a significant decrease of both enzyme amount and activity in both female and male animals Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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inbred Lewis strain euthyroid, hyperthyroid and hypothyroid male and female rats
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
-