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Literature summary for 1.1.1.75 extracted from

  • Cox, N.; Turner, J.M.; Willetts, A.J.
    Aminopropanol dehydrogenase activity in rat-liver preparations (1968), Biochim. Biophys. Acta, 170, 438-439.
    View publication on PubMed
Search for more literature for 1.1.1.75

Inhibitors

Inhibitors Comment Organism Structure
D,L-1-bromopropan-2-ol
-
 Rattus norvegicus
D,L-1-chloropropan-2-ol
-
 Rattus norvegicus
D,L-propan-1,2-diol
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4
-
 NAD+ for both enantiomers as substrate Rattus norvegicus
48
-
 L-1-Aminopropan-2-ol
-
 Rattus norvegicus
110
-
 D-1-aminopropan-2-ol
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-1-aminopropan-2-ol + NAD+ Rattus norvegicus
-
 aminoacetone + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0006
-
 for both enantiomers of 1-aminopropan-2-ol Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, 0.1 M phosphate buffer, pH 7, 6 days, no loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D,L-1-aminopropan-2-ol + NAD+ at high substrate concentrations both enantiomers utilized at the same rate, at low substrate concentration L-enantiomer preferred over D-enantiomer Rattus norvegicus aminoacetone + NADH
-
 ?
D-1-aminopropan-2-ol + NAD+
-
 Rattus norvegicus aminoacetone + NADH + H+
-
 r
L-1-aminopropan-2-ol + NAD+
-
 Rattus norvegicus aminoacetone + NADH
-
 ?
L-1-aminopropan-2-ol + NADP+ half maximum activity Rattus norvegicus aminoacetone + NADPH
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
20
-
 50% loss of activity after 24 h Rattus norvegicus
52
-
 78% loss of activity within 15 min Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
 Rattus norvegicus