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Literature summary for 1.1.1.71 extracted from

  • Lundova, T.; Zemanova, L.; Malcekova, B.; Skarka, A.; Stambergova, H.; Havrankova, J.; Safr, M.; Wsol, V.
    Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3) (2015), Chem. Biol. Interact., 234, 178-187.
    View publication on PubMed
Search for more literature for 1.1.1.71

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral-membrane protein Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NADPH + H+ Homo sapiens
-
 all-trans-retinol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography, and Superdex 200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
additional information no or very low expression in lungs, spleen, pancreas, large intestine and eye Homo sapiens
-
retina
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
thyroid gland highest expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+
-
 Homo sapiens ?
-
 ?
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+
-
 Homo sapiens ?
-
 ?
4-nitroacetophenone + NADPH + H+
-
 Homo sapiens ?
-
 ?
acetohexamide + NADPH + H+
-
 Homo sapiens ?
-
 ?
all-trans-retinal + NADPH + H+
-
 Homo sapiens all-trans-retinol + NADP+
-
 ?
DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens ?
-
 ?
estrone + NADPH + H+
-
 Homo sapiens ?
-
 ?
additional information 4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADH
-
 Homo sapiens
DHRS3
-
 Homo sapiens
retinal short-chain dehydrogenase/reductase member 3
-
 Homo sapiens
retSDR1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH the enzyme prefers NADPH as a cofactor Homo sapiens