Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.64 extracted from

  • Endahl, G.L.; Kochakian, C.D.; Hamm, D.
    Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17beta-hydroxy-(testosterone)dehydrogenase of guinea-pig liver (1960), J. Biol. Chem., 235, 2792-2796.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CuCl2 10 mM, 40% inhibition Cavia porcellus
FeCl3 10 mM, 54% inhibition Cavia porcellus
p-chloromercuribenzoate 10 mM, strong inhibition, 5% residual activity is reversed to 65% activity by either 1 mM glutathione or cysteine Cavia porcellus
Pb(NO3)2 10 mM, 30% inhibition Cavia porcellus
Sodium amytal 10 mM, 25% inhibition Cavia porcellus
Sodium cyanide 10 mM, progressive and marked inhibition Cavia porcellus
ZnCl2 10 mM, 90% inhibition Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0596
-
testosterone enzyme activity in microsomal fraction after centrifugation Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Cavia porcellus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Cavia porcellus
-
estrone + NADPH
-
r
testosterone + NADP+ Cavia porcellus
-
androst-4-ene-3,17-dione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
96.5
-
enzyme activity in microsomal fraction after centrifugation Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Cavia porcellus estrone + NADPH
-
r
testosterone + NADP+
-
Cavia porcellus androst-4-ene-3,17-dione + NADPH + H+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
sharp drop of activity above Cavia porcellus

pH Range

pH Minimum pH Maximum Comment Organism
8.5 10.5
-
Cavia porcellus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Cavia porcellus