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Literature summary for 1.1.1.64 extracted from

  • Inano, H.; Tamaoki, B.
    Purificatition and properties of NADP-dependent 17beta-hydroxysteoid dehydrogenase solubilized from porcine-testicular microsomal fraction (1974), Eur. J. Biochem., 44, 13-23.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
testosterone 1 mM, 62.8% inhibition of androstendione reduction Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Sus scrofa
-
estrone + NADPH
-
r
testosterone + NADP+ Sus scrofa
-
androst-4-ene-3,17-dione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
67.7
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Sus scrofa estrone + NADPH
-
r
testosterone + NADP+
-
Sus scrofa androst-4-ene-3,17-dione + NADPH + H+
-
r
testosterone + NADP+ rate of oxidation is less than 30% of those for reduction Sus scrofa androst-4-ene-3,17-dione + NADPH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Sus scrofa