Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.62 extracted from

  • Lin, S.X.; Shi, R.; Qiu, W.; Azzi, A.; Zhu, D.W.; Dabbagh, H.A.; Zhou, M.
    Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5 (2006), Mol. Cell. Endocrinol., 248, 38-46.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00003
-
estrone wild-type enzyme Homo sapiens
0.0003
-
estrone mutant enzyme L149V Homo sapiens
0.0043
-
dihydrotestosterone mutant enzyme L149V Homo sapiens
0.0046
-
estradiol-17beta wild-type enzyme Homo sapiens
0.01
-
estradiol-17beta mutant enzyme L149V Homo sapiens
0.0172
-
dehydroepiandrosterone mutant enzyme L149V Homo sapiens
0.033
-
dihydrotestosterone wild-type enzyme Homo sapiens
0.045
-
dehydroepiandrosterone wild-type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NADP+
-
Homo sapiens ?
-
?
dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens androstane-3beta,17beta-diol + NAD(P)+
-
?
estrone + NAD(P)H + H+
-
Homo sapiens estradiol-17beta + NAD(P)+
-
r

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase types 1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.12
-
dehydroepiandrosterone mutant enzyme L149V Homo sapiens
0.16
-
dehydroepiandrosterone wild-type enzyme Homo sapiens
0.24
-
estradiol-17beta mutant enzyme L149V Homo sapiens
0.26
-
estrone mutant enzyme L149V Homo sapiens
0.33
-
dihydrotestosterone wild-type enzyme Homo sapiens
0.34
-
dihydrotestosterone mutant enzyme L149V Homo sapiens
4.4
-
estradiol-17beta wild-type enzyme Homo sapiens
5.8
-
estrone wild-type enzyme Homo sapiens