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Literature summary for 1.1.1.62 extracted from

  • Brooks, J.D.; Thompson, L.U.
    Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells (2005), J. Steroid Biochem. Mol. Biol., 94, 461-467.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
enterodiol
-
Homo sapiens
enterolactone 0.05 mM, 84% inhibition Homo sapiens
genistein 0.05 mM, 59% inhibition Homo sapiens
additional information modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NAD(P)H + H+ Homo sapiens
-
estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H + H+
-
Homo sapiens estradiol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD type 1
-
Homo sapiens