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Literature summary for 1.1.1.62 extracted from

  • Blomquist, C.H.; Lima, P.H.; Tarrant, A.M.; Atkinson, M.J.; Atkinson, S.
    17beta-Hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae (2006), Comp. Biochem. Physiol. B Biochem. Mol. Biol., 143, 397-403.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
chrysin 0.02 mM, about 65% inhibition Montipora capitata
coumestrol 0.02 mM inhibits 90%, 0.0002 mM inhibits 50% Montipora capitata
daidzein 0.02 mM, about 75% inhibition Montipora capitata
genistein 0.02 mM, about 90% inhibition Montipora capitata
luteolin 0.02 mM, about 40% inhibition Montipora capitata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0058
-
NADP+
-
Montipora capitata
0.0113
-
estradiol-17beta
-
Montipora capitata

Organism

Organism UniProt Comment Textmining
Montipora capitata
-
-
-
Tubastraea coccinea
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+ activity with NAD+ is 2.2-3.8fold lower than with NADP+, depending on sample Tubastraea coccinea estrone + NADH + H+
-
?
estradiol-17beta + NAD+ activity with NAD+ is barely detectable Montipora capitata estrone + NADH + H+
-
?
estradiol-17beta + NADP+
-
Montipora capitata estrone + NADPH + H+
-
?
estradiol-17beta + NADP+
-
Tubastraea coccinea estrone + NADPH + H+
-
?
testosterone + NADP+ activity is 2.3-2.8fold lower than with estradiol-17beta, depending on sample Tubastraea coccinea 4-androstene-3,17-dione + NADPH + H+
-
?
testosterone + NADP+ activity is 22fold lower than with estradiol-17beta Montipora capitata 4-androstene-3,17-dione + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD
-
Montipora capitata
17beta-HSD
-
Tubastraea coccinea
17beta-hydroxysteroid dehydrogenase
-
Montipora capitata
17beta-hydroxysteroid dehydrogenase
-
Tubastraea coccinea

Cofactor

Cofactor Comment Organism Structure
NAD+ activity with NAD+ is 2.2-3.8fold lower than with NADP+, depending on sample Tubastraea coccinea
NAD+ activity with NAD+ is barely detectable Montipora capitata
NADP+
-
Montipora capitata
NADP+
-
Tubastraea coccinea