Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethylstilbestrol | strong inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | 17beta-HSD5 | Homo sapiens | 5829 | - |
microsome | 17beta-HSD2 | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD(P)+ | Homo sapiens | 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues | estrone + NAD(P)H | - |
? | |
estrone + NADPH + H+ | Homo sapiens | 17beta-HSD1, final step in the synthesis of active estrogens | estradiol-17beta + NADP+ | - |
? | |
testosterone + NAD(P)+ | Homo sapiens | 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues | 4-androstene-3,17-dione + NAD(P)H | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms 1, 2 and 5, 17beta-HSD1, 2 and 5 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ | 17beta-HSD2 and 5 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD2 also has 20alpha-HSD activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mucinous cystadenoma cell | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD(P)+ | - |
Homo sapiens | estrone + NAD(P)H | - |
? | |
estradiol-17beta + NAD(P)+ | 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues | Homo sapiens | estrone + NAD(P)H | - |
? | |
estrone + NADPH + H+ | 17beta-HSD1, final step in the synthesis of active estrogens | Homo sapiens | estradiol-17beta + NADP+ | - |
? | |
testosterone + NAD(P)+ | 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues | Homo sapiens | 4-androstene-3,17-dione + NAD(P)H | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | most effective cofactor for 17beta-HSD 2 and 5 | Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | 17beta-HSD1 | Homo sapiens |