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Literature summary for 1.1.1.62 extracted from

  • Langer, L.J.; Alexander, J.A.; Engel, L.L.
    Human placental estradiol-17beta dehydrogenase (1959), J. Biol. Chem., 234, 2609-2614.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0085
-
1-methyl-6-dehydroestradiol
-
Homo sapiens
0.012
-
11-ketoequilenin acetate
-
Homo sapiens
0.013
-
equilin
-
Homo sapiens
0.015
-
1-methylestradiol
-
Homo sapiens
0.02
-
equilenin
-
Homo sapiens
0.03
-
estradiol 3-methyl ether
-
Homo sapiens
0.032
-
4-methyl-1,3,5(10)-estratriene-1,17beta-diol
-
Homo sapiens
0.047
-
7-ketoestrone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dimethyl-6-dehydroestrone + NADH
-
Homo sapiens 1,2-dimethyl-6-dehydroestradiol + NAD+
-
?
1,2-dimethylestradiol + NAD+
-
Homo sapiens 1,2-dimethylestrone + NADH
-
r
1,2-dimethylestrone + NADH
-
Homo sapiens 1,2-dimethylestradiol + NAD+
-
r
1,4-diacetoxy-1,3,5(10)-estratrien-17-one + NADH
-
Homo sapiens 17beta-hydroxy-1,4-diacetoxy-1,3,5(10)-estratriene + NAD+
-
?
1,4-dihydroxy-1,3,5(10)-estratrien-17-one + NADH
-
Homo sapiens 1,4,17-trihydroxy-1,3,5(10)-estratrien + NAD+
-
?
1-methyl-6-dehydroestradiol + NAD+
-
Homo sapiens 1-methyl-6-dehydroestrone + NADH
-
r
1-methyl-6-dehydroestrone + NADH
-
Homo sapiens 1-methyl-6-dehydroestradiol + NAD+
-
r
1-methylestradiol + NAD+
-
Homo sapiens 1-methylestrone + NADH
-
?
11-ketoequilenin acetate + NADH
-
Homo sapiens 17beta-hydroxy-11-ketoequilenin acetate + NAD+
-
?
11alpha-hydroxyestradiol + NAD+
-
Homo sapiens 11alpha-hydroxyestrone + NADH
-
?
11beta-hydroxyestradiol + NAD+
-
Homo sapiens 11beta-hydroxyestrone + NADH
-
?
16-ketoestrone + NADH
-
Homo sapiens 16-ketoestradiol + NAD+
-
?
18-nor-D-homoestrone 3-methyl ether + NADH
-
Homo sapiens 18-nor-D-homoestradiol 3-methyl ether + NAD+
-
?
19-nortestosterone + NAD+ 2% of the activity with estradiol-17beta Homo sapiens 4-estren-3,17-dione + NADH
-
?
2,4-dinitroestradiol + NAD+
-
Homo sapiens 2,4-dinitroestrone + NADH
-
r
2,4-dinitroestrone + NADH
-
Homo sapiens 2,4-dinitroestradiol + NAD+
-
r
2,4-dinitroestrone 3-oxyacetic acid ether + NADH
-
Homo sapiens 2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+
-
?
2,5(10)-estradiene-1,4,17-trione + NADH
-
Homo sapiens 17beta-hydroxy-2,5(10)-estradiene-1,4-dione + NAD+
-
?
2-aminoestradiol + NAD+
-
Homo sapiens 2-aminoestrone + NADH
-
?
2-methoxyestrone + NADH
-
Homo sapiens 2-methoxyestradiol + NAD+
-
?
2-methylestradiol + NAD+
-
Homo sapiens 2-methylestrone + NADH
-
?
2-nitroestradiol + NAD+
-
Homo sapiens 2-nitroestrone + NADH
-
r
2-nitroestrone + NADH
-
Homo sapiens 2-nitroestradiol + NAD+
-
r
2-nitroestrone 3-oxyacetic acid ester + NADH + H+
-
Homo sapiens 2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+
-
?
3-hydroxy-2,5(10)-estradiene-1,4,17-trione + NADH
-
Homo sapiens 3,17beta-dihydroxy-2,5(10)-estradiene-1,4-dione + NAD+
-
?
3-O-methyl-17beta-estradiol + NAD+
-
Homo sapiens 3-O-methylestrone + NADH
-
?
4-aminoestrone + NADH
-
Homo sapiens 4-aminoestradiol + NAD+
-
?
4-aminoestrone 3,4-diacetate + NADH
-
Homo sapiens 4-aminoestradiol 3,4-diacetate + NAD+
-
?
4-methyl-1,3,5(10)-estratriene-1,17beta-diol + NAD+
-
Homo sapiens 1-hydroxy-4-methyl-1,3,5(10)-estratriene-17-one + NADH
-
?
4-nitrestrone + NADH
-
Homo sapiens 4-nitroestradiol + NAD+
-
r
4-nitroestradiol + NAD+
-
Homo sapiens 4-nitroestrone + NADH
-
r
5,7,9-estratrien-3beta-ol-17-one + NADH
-
Homo sapiens 5,7,9-estratriene-3beta,17beta-diol + NAD+
-
?
5,7,9-estratriene-3beta,17beta-diol + NAD+
-
Homo sapiens 5,7,9-estratriene-3beta-ol-17-one + NADH
-
?
6-dehydroestrone 3-benzoate + NADH
-
Homo sapiens 6-dehydro-17beta-estradiol 3-benzoate + NAD+
-
?
6-ketoestrone + NADH
-
Homo sapiens 6-ketoestradiol-17beta + NAD+
-
?
6alpha,7alpha-dihydroxyestrone + NADH
-
Homo sapiens 6alpha,7alpha-dihydroxyestradiol + NAD+
-
?
6alpha-hydroxyestradiol + NAD+
-
Homo sapiens 6alpha-hydroxyestrone + NADH
-
?
7-ketoestrone + NADH
-
Homo sapiens 7-ketoestradiol-17beta + NAD+
-
?
7alpha-hydroxyestradiol + NAD+
-
Homo sapiens 7alpha-hydroxyestrone + NADH
-
?
7alpha-hydroxyestrone + NADH
-
Homo sapiens 7alpha-hydroxyestradiol + NAD+
-
r
7beta-hydroxyestrone + NADH
-
Homo sapiens 7beta-hydroxyestradiol + NAD+
-
?
DL-3-deoxyequilenin + NADH
-
Homo sapiens 17beta-hydroxy-DL-3-deoxyequilin + NAD+
-
?
DL-6-methoxy-3-deoxy-equilenin + NADH + H+
-
Homo sapiens 17beta-hydroxy-DL-6-methoxy-3-deoxyequilenin + NAD+
-
?
equilenin + NADH
-
Homo sapiens 17beta-hydroxyequilenin + NAD+
-
?
equilin + NADH
-
Homo sapiens 17beta-hydroxyequilin + NAD+
-
?
estradiol-17beta + NAD+
-
Homo sapiens estrone + NADH
-
?
estrone 3-methyl ether + NADH
-
Homo sapiens 3-O-methyl-17beta-estradiol + NAD+
-
?
estrone 3-oxyacetic acid ether + NADH
-
Homo sapiens 17beta-estradiol 3-O-oxyacetic acid ether + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Homo sapiens