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Literature summary for 1.1.1.62 extracted from

  • Blomquist, C.H.; Lindemann, N.J.; Hakanson, E.Y.
    17beta-Hydroxysteroid and 20alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity (1985), Arch. Biochem. Biophys., 239, 206-215.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information activity with estradiol-17beta is not inhibited by high concentrations of C19-steroids or C21-steroids Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0008
-
estradiol-17beta
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
Homo sapiens
-
breast cell line
-
Homo sapiens
-
CAOV-3 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MCF-7 cell breast cancer cell line MCF-7 Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-231 cell breast cancer cell line MDA-MB-231 Homo sapiens
-
ovarian cancer cell
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-
placenta
-
Homo sapiens
-
T47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+
-
Homo sapiens estrone + NADH
-
?
testosterone + NADP+
-
Homo sapiens 4-androstene-3,17-dione + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Homo sapiens