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Literature summary for 1.1.1.54 extracted from
- Triphosphopyridine nucleotide-allyl and -ethyl alcohol dehydrogenases from Escherichia coli (preliminary report) (1958), J. Gen. Appl. Microbiol., 4, 211-215.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyanide | - |
Escherichia coli |  |
| dipyridyl | - |
Escherichia coli | |
| EDTA | - |
Escherichia coli | |
| additional information | not: monoiodoacetate | Escherichia coli | |
| p-chloromercuribenzoate | can be overcome by addition of gluthathione | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
NADP+ | - |
Escherichia coli | |
| 5 | - |
allyl-alcohol | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | is sensitive against metal ion chelators | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| allyl alcohol + NADP+ | Escherichia coli | - |
acrolein + NADPH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
about 70,1 unit of enzyme activity defined as amount of enzyme which causes a change in optical density of 0.001 per minute | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-butylene glycol + NADP+ | - |
Escherichia coli | ? | - |
r | |
| allyl alcohol + NADP+ | - |
Escherichia coli | acrolein + NADPH | - |
r | |
| saturated primary alcohols + NADP+ | i.e. ethyl alcohol, n-propyl alcohol, n-butyl acohol, isobutyl alcohol, propylene glycol | Escherichia coli | ? | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
in Tris-buffer | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD(P)H | - |
Escherichia coli | |
| NADP+ | specific for | Escherichia coli | |
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Release 2023.1 (January 2023)
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