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Literature summary for 1.1.1.53 extracted from

  • Tokarz, J.; Norton, W.; M๖ller, G.; Hrabe de Angelis, M.; Adamski, J.
    Zebrafish 20beta-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response (2013), PLoS ONE, 8, e54851.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Danio rerio
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-
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Synonyms

Synonyms Comment Organism
20beta-HSD type 2
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Danio rerio

Expression

Organism Comment Expression
Danio rerio transcripts are up-regulated upon cortisol treatment. A cortisol-independent, short-term physical stressor leads to the up-regulation of isoforms 11beta-HSD2 and 20beta-HSD2 expression along with several hypothalamus-pituitary-interrenal axis genes up

General Information

General Information Comment Organism
physiological function isoform 20beta-HSD type 2 is involved in cortisol catabolism and stress response. The morpholino-induced knock-down of gene expression in zebrafish embryos reveals no developmental phenotype under normal culture conditions, but prominent effects are observed after a cortisol challenge. 20beta-Hydroxycortisone is not a physiological ligand for the zebrafish glucocorticoid or mineralocorticoid receptor but is excreted into the fish holding water Danio rerio