Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
20beta-HSD type 2 | - |
Danio rerio |
Organism | Comment | Expression |
---|---|---|
Danio rerio | transcripts are up-regulated upon cortisol treatment. A cortisol-independent, short-term physical stressor leads to the up-regulation of isoforms 11beta-HSD2 and 20beta-HSD2 expression along with several hypothalamus-pituitary-interrenal axis genes | up |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform 20beta-HSD type 2 is involved in cortisol catabolism and stress response. The morpholino-induced knock-down of gene expression in zebrafish embryos reveals no developmental phenotype under normal culture conditions, but prominent effects are observed after a cortisol challenge. 20beta-Hydroxycortisone is not a physiological ligand for the zebrafish glucocorticoid or mineralocorticoid receptor but is excreted into the fish holding water | Danio rerio |