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Literature summary for 1.1.1.51 extracted from

  • Aceves-Ramos, A.; de la Torre, P.; Hinojosa, L.; Ponce, A.; Garcํa-Villegas, R.; Laclette, J.P.; Bobes, R.J.; Romano, M.C.
    Cloning, characterization and functional expression of Taenia solium 17 beta-hydroxysteroid dehydrogenase (2014), Gen. Comp. Endocrinol., 203, 186-192.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning by in silico blast searches in the Taenia solium genome database and RT-PCR, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, transient recombinant expression in HEK-293T cells Taenia solium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Taenia solium poor activity with estrone ?
-
?
testosterone + NADP+ Taenia solium
-
androstenedione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Taenia solium
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cyst
-
Taenia solium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information poor activity with estrone Taenia solium ?
-
?
testosterone + NADP+
-
Taenia solium androstenedione + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
17beta-HSD
-
Taenia solium
17beta-hydroxysteroid dehydrogenases
-
Taenia solium

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Taenia solium
NADPH
-
Taenia solium

General Information

General Information Comment Organism
evolution enzyme Tsol-17betaHSD belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily, it shares motifs and activity with the type 3 enzyme of some other species Taenia solium
physiological function 17beta-hydroxysteroid dehydrogenases (17beta-HSD) are key enzymes involved in the formation (reduction) and inactivation (oxidation) of sex steroids. Taenia solium cysticerci are able to synthesize sex steroid hormones in vitro when precursors are provided in the culture medium Taenia solium