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Literature summary for 1.1.1.51 extracted from

  • Tóth, I.; Szécsi, M.; Julesz, J.; Faredin I.
    Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin (1997), Skin Pharmacol. Physiol., 10, 160-168.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-MA
-
Homo sapiens
cyproterone acetate
-
Homo sapiens
epostane
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00001
-
dehydroepiandrosterone 37°C, pH not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000000935
-
female abdominal skin, mean value, n=4, 37°C, pH not specified in the publication Homo sapiens
0.0000000122
-
male inguinal skin, mean value, n=8, 37°C, pH not specified in the publication Homo sapiens
0.0000000213
-
female perineal skin, mean value, n=4, 37°C, pH not specified in the publication Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
Homo sapiens androstene-3,17-dione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase
-
Homo sapiens
DELTA5-3beta-hydroxysteroid dehydrogenase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000145
-
37°C, pH not specified in the publication Homo sapiens 4-MA
0.0000062
-
37°C, pH not specified in the publication Homo sapiens epostane
0.00015
-
37°C, pH not specified in the publication Homo sapiens cyproterone acetate