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Literature summary for 1.1.1.51 extracted from

  • Chapman, J.C.; Polanco, J.R.; Min, S.; Michael, S.D.
    Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis (2005), Reprod. Biol. Endocrinol., 3, 11.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-
mitochondrion
-
Mus musculus 5739
-
additional information the enzyme is distributed between microsomes and mitochondria, the HSD activity in microsomes is predominant throughout the follicular phase of the estrous cycle, the enzyme activity is increased in pregnant mice uteri including embryos, overview Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + NAD+ Mus musculus the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview progesterone + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
female (C3H/HeJ × 129/J)F1 (C31) hybrid mice
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from ovaries and pregnant uteri including embryos by subcellular fractionation of minced homogenates Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
corpus luteum
-
Mus musculus
-
ovary
-
Mus musculus
-
uterus taken from 10-20 days pregnant mice for enzyme extraction including the embryo Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + NAD+
-
Mus musculus progesterone + NADH + H+
-
?
pregnenolone + NAD+ the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview Mus musculus progesterone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3 beta-hydroxysteroid dehydrogenase
-
Mus musculus
HSD
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus