Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | the hydrophobic 17beta-HSD3 is membrane-bound through an N-terminal transmembrane domain | Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | Homo sapiens | isozymes 17beta-HSD3 and 17beta-HSD5 | testosterone + NADP+ | - |
r | |
5-androstenedione + NADPH | Homo sapiens | isozyme 17beta-HSD3 | 5alpha-dihydrotestosterone + NADP+ | - |
r | |
additional information | Homo sapiens | the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes 17beta-HSD3 and 17beta-HSD5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | isozyme 17beta-HSD5 | Homo sapiens | - |
gonad | isozymes 17beta-HSD3 and 17beta-HSD5 | Homo sapiens | - |
liver | isozyme 17beta-HSD5 | Homo sapiens | - |
prostate gland | isozyme 17beta-HSD5 | Homo sapiens | - |
testis | high expression level of isozyme 17beta-HSD5 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | isozymes 17beta-HSD3 and 17beta-HSD5 | Homo sapiens | testosterone + NADP+ | - |
r | |
5-androstenedione + NADPH | isozyme 17beta-HSD3 | Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
r | |
additional information | the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis | Homo sapiens | ? | - |
? | |
additional information | isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD3 | - |
Homo sapiens |
17beta-HSD5 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Homo sapiens |