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Literature summary for 1.1.1.51 extracted from

  • Luu-The, V.; Tremblay, P.; Labrie, F.
    Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women (2006), Mol. Endocrinol., 20, 437-443.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of type 3 17beta-HSD in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-HSD, the bisubstrate inhibitors are less potent in intact cells than in homogenated cells, overview, the best inhibitors of that series are those bearing an alkyl side-chain spacer of 11 or 12 methylenes with inhibition of 69% and 78% at 1 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is an important therapeutic target for androgen-sensitive diseases, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+ selective reduction at C17 Homo sapiens testosterone + NADP+
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?
additional information the enzyme is an important therapeutic target for androgen-sensitive diseases, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD
-
Homo sapiens
type 3 17beta-HSD
-
Homo sapiens
type 3 17beta-hydroxysteroid dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens