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Literature summary for 1.1.1.50 extracted from

  • Meyer, L.; Venard, C.; Schaeffer, V.; Patte-Mensah, C.; Mensah-Nyagan, A.G.
    The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury (2008), Neurobiol. Dis., 30, 30-41.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for treatment of chronic pain in neuropathic diseases, overview Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
x * 33000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3alpha,5alpha-allopregnenolone + NAD(P)+ Rattus norvegicus i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview 5alpha-dihydroprogesterone + NAD(P)H
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sciatic nerve lumbar, of naive, sham-operated and neuropathic rats, enzyme expression analysis and cellular distribution in neurons and glial cells, immunohistochemic analysis, overview Rattus norvegicus
-
spinal cord abundant enzyme expression Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha,5alpha-allopregnenolone + NAD(P)+ i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview Rattus norvegicus 5alpha-dihydroprogesterone + NAD(P)H
-
r
3alpha,5alpha-allopregnenolone + NAD(P)+ i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP Rattus norvegicus 5alpha-dihydroprogesterone + NAD(P)H
-
r

Subunits

Subunits Comment Organism
? x * 33000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
3alpha-HSOR
-
Rattus norvegicus
3alpha-hydroxysteroid oxido-reductase
-
Rattus norvegicus
More cf. EC 1.1.1.213 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Rattus norvegicus
NAD(P)H
-
Rattus norvegicus