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Literature summary for 1.1.1.50 extracted from

  • Stayrook, K.R.; Rogers, P.M.; Savkur, R.S.; Wang, Y.; Su, C.; Varga, G.; Bu, X.; Wei, T.; Nagpal, S.; Liu, X.S.; Burris, T.P.
    Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha (2008), Mol. Pharmacol., 73, 607-612.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment with 0.002 mM T0901317 induces about 2fold AKR1C4 mRNA expression, liver X receptor alpha mediates transcriptional activation of the AKR1C4 gene, leading to increased AKR1C4 protein expression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of the enzyme with the LXR alpha receptor in HuH7 and HepG2 cells Homo sapiens
expressed in Hu-H7 cells and Hep-G2 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens type I human hepatic 3alpha-hydroxysteroid dehydrogenase plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism, the enzyme is regulated by expression level of the liver X receptor alpha, i.e. LXRalpha [NR1H3], a nuclear hormone receptor, predictive response element modeling and whole genome analysis of LXRalpha occupancy sites using ChIP/microarray technology, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information type I human hepatic 3alpha-hydroxysteroid dehydrogenase plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism, the enzyme is regulated by expression level of the liver X receptor alpha, i.e. LXRalpha [NR1H3], a nuclear hormone receptor, predictive response element modeling and whole genome analysis of LXRalpha occupancy sites using ChIP/microarray technology, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
3 alpha-hydroxysteroid dehydrogenase
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Homo sapiens
3alpha-hydroxysteroid dehydrogenase
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Homo sapiens
AKR1C4
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Homo sapiens
type I 3alpha-HSD
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Homo sapiens