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Literature summary for 1.1.1.50 extracted from
- Intestinal and hepatic microsomal metabolism of testosterone and progesterone by a 3alpha-hydroxysteroid dehydrogenase to the 3alpha-hydroxy derivatives in the channel catfish, Ictalurus punctatus (2002), J. Steroid Biochem. Mol. Biol., 82, 413-424.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Ictalurus punctatus | |
| 0.119 | - |
testosterone | pH 7.4, 35°C, 3alpha-hydroxysteroid dehydrogenase activity | Ictalurus punctatus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Ictalurus punctatus | - |
- |
| additional information | no 3alpha-hydroxysteroid dehydrogenase activity in cytosol | Ictalurus punctatus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ictalurus punctatus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | proximal and distal, mucosa | Ictalurus punctatus | - |
| liver | - |
Ictalurus punctatus | - |
| mucosa | - |
Ictalurus punctatus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000023 | - |
3alpha-hydroxysteroid dehydrogenase activity in the liver | Ictalurus punctatus |
| 0.00000027 | - |
3alpha-hydroxysteroid dehydrogenase activity in the proximal intestine | Ictalurus punctatus |
| 0.00000032 | - |
3alpha-hydroxysteroid dehydrogenase activity in the distal intestine | Ictalurus punctatus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| testosterone + NADPH + H+ | - |
Ictalurus punctatus | 4-androstene-3alpha,17beta-diol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3alpha-HSD | - |
Ictalurus punctatus |
| 3alpha-hydroxysteroid dehydrogenase | - |
Ictalurus punctatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
assay at | Ictalurus punctatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Ictalurus punctatus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Ictalurus punctatus | |
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Release 2023.1 (January 2023)
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