Literature summary for 1.1.1.50 extracted from

Gao, C.Q.; Dhooge, W.S.; Kaufman, J.M.; Weyne, J.J.; Eechaute, W.P.
Hypothalamic 5alpha-reductase and 3alpha-oxidoreductase activity in the male rat (2002), J. Steroid Biochem. Mol. Biol., 80, 91-98.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+	Rattus norvegicus	-	5alpha-pregnan-3,20-dione + NADPH + H+	-	r
3alpha-hydroxypregn-4-en-20-one + NADP+	Rattus norvegicus	-	pregn-4-en-3,20-dione + NADPH + H+	-	?
additional information	Rattus norvegicus	the high 3alpha-oxidoreductase activity in the hypothalamus of prepubertal rats is not related to the gonadal or adrenal steroids, the products are found in both prepubertal, mature, and castrated rats, rats with adrenalectomy show elevated enzyme activities, 3alpha-hydroxy progesterone is not related to the regulation of gonadotropin secretion in the male rat	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypothalamus	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	age-dependent activities in vivo	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3alpha,5alpha,20alpha-trihydroxyprogesterone + NADP+	-	Rattus norvegicus	5alpha,20alpha-dihydroxyprogesterone-3-one + NADPH + H+	-	r
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+	-	Rattus norvegicus	5alpha-pregnan-3,20-dione + NADPH + H+	-	r
3alpha-hydroxypregn-4-en-20-one + NADP+	-	Rattus norvegicus	pregn-4-en-3,20-dione + NADPH + H+	-	?
additional information	the high 3alpha-oxidoreductase activity in the hypothalamus of prepubertal rats is not related to the gonadal or adrenal steroids, the products are found in both prepubertal, mature, and castrated rats, rats with adrenalectomy show elevated enzyme activities, 3alpha-hydroxy progesterone is not related to the regulation of gonadotropin secretion in the male rat	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
3alpha-OR	-	Rattus norvegicus
3alpha-oxidoreductase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Rattus norvegicus
NADPH	-	Rattus norvegicus

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Release 2023.1 (January 2023)