KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.235 | - |
5beta-Pregnan-3alpha-ol-20-one | cytosolic NADH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | Digitalis purpurea | |
0.4 | - |
NADH | cytosolic NADH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | Digitalis purpurea | |
0.91 | - |
NADPH | cytosolic NADH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | Digitalis purpurea | |
1.33 | - |
NADPH | microsomal NADPH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | Digitalis purpurea |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | NADH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, 97% in the cytosol | Digitalis purpurea | 5829 | - |
microsome | low activity of NADPH-linked 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Digitalis purpurea | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | Digitalis purpurea | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, NADPH and NADH possible as cofactors | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
? | |
5beta-pregnan-3,20-dione + NAD(P)H | Digitalis purpurea | 3alpha-hydroxysteroid-5beta-oxidoreductase activity | 3alpha-hydroxy-5beta-pregnan-20-one + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Digitalis purpurea | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
shoot | culture | Digitalis purpurea | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha-hydroxy-5beta-pregnan-20-one + NADP+ | - |
Digitalis purpurea | 5beta-pregnan-3,20-dione + NADPH | - |
r | |
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, NADPH and NADH possible as cofactors | Digitalis purpurea | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
? | |
5beta-pregnan-3,20-dione + NAD(P)H | 3alpha-hydroxysteroid-5beta-oxidoreductase activity | Digitalis purpurea | 3alpha-hydroxy-5beta-pregnan-20-one + NAD(P)+ | - |
r | |
5beta-pregnane-3,20-dione + NADH + H+ | - |
Digitalis purpurea | 5beta-pregnan-3alpha-ol-20-one + NAD+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid-5beta-oxidoreductase | - |
Digitalis purpurea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Digitalis purpurea | |
NADH | cytosolic 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Digitalis purpurea | |
NADPH | NADPH-linked microsomal 5beta-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase shows very low activity only with NADPH | Digitalis purpurea |