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Literature summary for 1.1.1.50 extracted from

  • Iyer, R.B.; Binstock, J.M.; Schwartz, I.S.; Gordon, G.G.; Weinstein, B.I.; Southern, A.L.
    Purification and properties of human hepatic 3alpha-hydroxysteroid dehydrogenase (1992), J. Steroid Biochem. Mol. Biol., 43, 343-349.
    View publication on PubMed

General Stability

General Stability Organism
stable in phosphate 50 mM plus 10-20% glycerol at 4°C, while freezing and thawing results in a great loss of enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dexamethasone
-
Homo sapiens
dexamethasone 21-acetate
-
Homo sapiens
dexamethasone 21-hemisuccinate
-
Homo sapiens
testosterone at concentration 0.001 mM 75% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
5beta-Dihydrocortisol
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrocortisol + NADPH
-
Homo sapiens 3alpha,5alpha-tetrahydrocortisol + NADP+
-
?
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
?
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+
-
?
5beta-dihydrocortisol + NADPH
-
Homo sapiens 3alpha,5beta-tetrahydrocortisol + NADP+
-
?
5beta-dihydrotestosterone + NAD(P)H
-
Homo sapiens 5beta-androstan-3alpha,17beta-diol + NAD(P)+
-
?
additional information a saturated 4,5 double bound is essential for enzyme activity, 3-ketosteroids are not used as substrates Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 37000, SDS-PAGE Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.8 7.4
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH preference for Homo sapiens