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Literature summary for 1.1.1.50 extracted from

  • Chetyrkin, S.V.; Belyaeva, O.V.; Gough, W.H.; Kedishvili, N.Y.
    Characterization of a novel type of human microsomal 3alpha-hydroxysteroid dehydrogenase (2001), J. Biol. Chem., 276, 22278-22286.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus system with Sf9 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
3alpha-tetrahydroprogesterone
-
Homo sapiens
0.012
-
5alpha-dihydrotestosterone
-
Homo sapiens
0.024
-
androsterone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
1-4 different enzyme isoforms
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information variations in different tissues concerning number of enzyme isoforms Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0135
-
-
Homo sapiens
0.031
-
substrate dihydrotestosterone Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxy-dihydrotestosterone + NAD+
-
Homo sapiens 5alpha-androstan-3,17-dione + NADH
-
r
3alpha-tetrahydroprogesterone + NADH
-
Homo sapiens 5alpha-dihydroprogesterone + NAD+
-
r
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADPH
-
r
5alpha-androstan-3alpha,17beta-diol + NAD(P)H
-
Homo sapiens 5alpha-dihydrotestosterone + NAD(P)+
-
r
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
r
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+
-
r
androsterone + NAD(P)+
-
Homo sapiens 5alpha-androstan-3,17-dione + NAD(P)H
-
r

Cofactor

Cofactor Comment Organism Structure
additional information cytosolic and microsomal enzymes have different cofactor preferences: cytosolic enzymes prefer NADP+/NADPH, microsomal prefer NAD+/NADH Homo sapiens
NAD+ preference for Homo sapiens
NADH preference for Homo sapiens