Literature summary for 1.1.1.49 extracted from

Lin, H.R.; Wu, C.C.; Wu, Y.H.; Hsu, C.W.; Cheng, M.L.; Chiu, D.T.
Proteome-wide dysregulation by glucose-6-phosphate dehydrogenase (G6PD) reveals a novel protective role for G6PD in aflatoxin B1-mediated cytotoxicity (2013), J. Proteome Res., 12, 3434-3448.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glucose 6-phosphate + NADP+	Homo sapiens	-	6-phospho-D-glucono-1,5-lactone + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11413	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + NADP+	-	Homo sapiens	6-phospho-D-glucono-1,5-lactone + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
G6PD	-	Homo sapiens
glucose-6-phosphate dehydrogenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	cells with glucose-6-phosphate dehydrogenase deficiency are susceptible to oxidant-induced death at high oxidative stress	Homo sapiens
physiological function	the enzyme plays a protective role of in aflatoxin B1-induced cytotoxicity	Homo sapiens

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Release 2023.1 (January 2023)