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Literature summary for 1.1.1.49 extracted from

  • Ibrahim, M.; Ghazy, A.; Salem, A.; Ghazy, M.; Abdel-Monsef, M.
    Purification and characterization of glucose-6-phosphate dehydrogenase from camel liver (2014), Enzyme Res., 2014, 714054.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ADP about 65% inhibition at 5 mM Camelus dromedarius
Ca2+ about 90% residual activity at 2 mM Camelus dromedarius
Cu2+ about 15% residual activity at 5 mM Camelus dromedarius
D-glucose 6-phosphate about 48% inhibition at 5 mM Camelus dromedarius
dithiothreitol about 40% inhibition at 5 mM Camelus dromedarius
Fe2+ about 30% residual activity at 5 mM Camelus dromedarius
additional information less than 8% inhibition with 1,10-phenanthroline, ATP, EDTA, and iodoacetamide. Not inhibited by NAD+ Camelus dromedarius
NADH about 38% inhibition at 5 mM Camelus dromedarius
NADPH about 90% inhibition at 0.2 mM Camelus dromedarius
Ni2+ about 95% residual activity at 2 mM Camelus dromedarius
phenylmethylsulfonyl fluoride about 48% inhibition at 5 mM Camelus dromedarius
Zn2+ about 50% residual activity at 5 mM Camelus dromedarius

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.081
-
NADP+ at pH 8.0 temperature not specified in the publication Camelus dromedarius

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ about 110% activity at 5 mM Camelus dromedarius
Mg2+ about 135% activity at 5 mM Camelus dromedarius
Mn2+ about 115% activity at 5 mM Camelus dromedarius

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
3 * 64000, SDS-PAGE Camelus dromedarius
194000
-
gel filtration Camelus dromedarius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NADP+ Camelus dromedarius
-
6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Camelus dromedarius
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, DEAE cellulose column chromatography, Sephacryl S-300 gel filtration, and 2',5' ADP Sepharose 4B affinity chromatography Camelus dromedarius

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Camelus dromedarius
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0286
-
crude extract, at pH 8.0 temperature not specified in the publication Camelus dromedarius
1.804
-
after 63.09fold purification, at pH 8.0 temperature not specified in the publication Camelus dromedarius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Camelus dromedarius 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Subunits

Subunits Comment Organism
homotrimer 3 * 64000, SDS-PAGE Camelus dromedarius

Synonyms

Synonyms Comment Organism
beta-D-glucose-6-phosphate; NADP oxidoreductase
-
Camelus dromedarius
G6PD
-
Camelus dromedarius
glucose-6-phosphate dehydrogenase
-
Camelus dromedarius

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Camelus dromedarius

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 more than 50% activity between pH 6.5 and 8.5 Camelus dromedarius

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Camelus dromedarius

pI Value

Organism Comment pI Value Maximum pI Value
Camelus dromedarius isoelectric focusing 6.8 6.6