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Literature summary for 1.1.1.49 extracted from

  • Kohan, A.B.; Talukdar, I.; Walsh, C.M.; Salati, L.M.
    A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids (2009), Biochem. Biophys. Res. Commun., 388, 117-121.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary hepatocyte Rattus norvegicus
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Expression

Organism Comment Expression
Rattus norvegicus the AMPK signaling pathway as well as the inhibitory p38 MAPK pathway are cooperating to inhibit G6PD expression. Arachidonic acid activates AMP-activated protein kinase in primary rat hepatocytes, and this effect is p38 MAPK-dependent. Activation of AMP-activated protein kinase mimics the inhibition by arachidonic acid of the insulin-mediated induction of G6PD. Overexpression of dominant-negative AMP-activated protein kinase abolishes the effect of arachidonic acid on G6PD expression down