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Literature summary for 1.1.1.49 extracted from

  • Minucci, A.; Giardina, B.; Zuppi, C.; Capoluongo, E.
    Glucose-6-phosphate dehydrogenase laboratory assay: How, when, and why? (2009), IUBMB Life, 61, 27-34.
    View publication on PubMed

Application

Application Comment Organism
medicine G6PD deficiency is the commonest clinically significant enzymopathy in humans. More than 400 million people worldwide are affected by this condition which may determine favism, drug-induced acute hemolytic anemia, severe chronic nonspherocytic haemolytic anemia, neonatal jaundice and hemolytic anemia associated with viral or microbiological infections. The highest prevalence of G6PD deficiency mainly regards tropical Africa, the Middle East, tropical and subtropical Asia, Papua New Guinea, and various Mediterranean regions, for example Sardinia island. G6PD deficiency may represent a selective advantage due to the increased resistance to severe Plasmodium falciparum infection of the affected individuals. G6PD/pyruvate kinase ratio is more reliable than the G6PD activity alone, for the identification of G6PD heterozygotes, especially in patients with microcytic anemia. G6PD/6PDG ratio is an absolute measure of G6PD deficiency of female carriers Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
tetramer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
G6PD
-
Homo sapiens