Application | Comment | Organism |
---|---|---|
medicine | G6PD deficiency due to its polymorphism causes neonatal jaundice, acute hemolysis in malaria, favism, severe chronic non-spherocytic hemolytic anemia, and lipid dysregulation. G6PD deficiency may be responsible for the high incidence of coronary artery disease among African-Americans and reduces mortality due to ischemic heart disease and cerebrovascular disease in Sardinian males. In Mediterranean and Sardinian G6PD-deficient individuals, G6PD deficiency may confer a partial protection against atherosclerosis, leading to a reduced risk of cardiovascular diseases in G6PD-deficient individuals. G6PD appears to be an attractive therapeutic target for diabetes-induced cardiomyopathy, ischemic cardiomyopathy, pulmonary hypertension, angiotensin II-induced hypertension, vascular smooth muscle hypertrophy and coronary disease in humans | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-amino-NAD+ | irreversibly inhibits G6PD | Saccharomyces cerevisiae | |
6-amino-NADP+ | irreversibly inhibits G6PD | Saccharomyces cerevisiae | |
dehydroepiandrosterone | non-competitively inhibits | Homo sapiens | |
epiandrosterone | non-competitively inhibits | Homo sapiens | |
additional information | hyperaldosteronism downregulates G6PD and whereby decreases GSH levels and conversely increases oxidative stress, which evokes endothelial-derived NO and impairs vascular function | Homo sapiens | |
additional information | inhibition of G6PD protects rat hearts from ischemia-reperfusion injury induced by oxidative stress | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | liver, lungs and heart | Rattus norvegicus | 5829 | - |
microsome | liver, lungs and heart | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | G6PD is more than 2fold higher in pulmonary arteries compared with coronary arteries | Bos taurus | - |
blood vessel | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | G6PD is more than 2fold higher in rat lungs than in rat hearts | Rattus norvegicus | - |
neutrophil | pregnant women, G6PD translocates to microtubule-organizing centers | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NADP+ | - |
Homo sapiens | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? | |
additional information | G6PD overexpressed in adipocytes in obese (including db/db, ob/ob and diet-induced obesity) mice, in adipocytes and stromal-vascular cells in diabetic db/db mice, and in adipocytes cultured under high-glucose conditions in vitro induces the expression of NADPH oxidase and leads to an increase in oxidative stress | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G6PD | - |
Mus musculus |
G6PD | - |
Homo sapiens |
G6PD | - |
Rattus norvegicus |
G6PD | - |
Saccharomyces cerevisiae |
G6PD | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | G6PD activity is regulated by the intracellular NADP+ levels and the NADPH/NADP+ ratio | Homo sapiens |