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Literature summary for 1.1.1.49 extracted from

  • Gupte, S.A.
    Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases (2008), Curr. Opin. Investig. Drugs, 9, 993-1000.
    View publication on PubMed

Application

Application Comment Organism
medicine G6PD deficiency due to its polymorphism causes neonatal jaundice, acute hemolysis in malaria, favism, severe chronic non-spherocytic hemolytic anemia, and lipid dysregulation. G6PD deficiency may be responsible for the high incidence of coronary artery disease among African-Americans and reduces mortality due to ischemic heart disease and cerebrovascular disease in Sardinian males. In Mediterranean and Sardinian G6PD-deficient individuals, G6PD deficiency may confer a partial protection against atherosclerosis, leading to a reduced risk of cardiovascular diseases in G6PD-deficient individuals. G6PD appears to be an attractive therapeutic target for diabetes-induced cardiomyopathy, ischemic cardiomyopathy, pulmonary hypertension, angiotensin II-induced hypertension, vascular smooth muscle hypertrophy and coronary disease in humans Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-amino-NAD+ irreversibly inhibits G6PD Saccharomyces cerevisiae
6-amino-NADP+ irreversibly inhibits G6PD Saccharomyces cerevisiae
dehydroepiandrosterone non-competitively inhibits Homo sapiens
epiandrosterone non-competitively inhibits Homo sapiens
additional information hyperaldosteronism downregulates G6PD and whereby decreases GSH levels and conversely increases oxidative stress, which evokes endothelial-derived NO and impairs vascular function Homo sapiens
additional information inhibition of G6PD protects rat hearts from ischemia-reperfusion injury induced by oxidative stress Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol liver, lungs and heart Rattus norvegicus 5829
-
microsome liver, lungs and heart Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery G6PD is more than 2fold higher in pulmonary arteries compared with coronary arteries Bos taurus
-
blood vessel
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung G6PD is more than 2fold higher in rat lungs than in rat hearts Rattus norvegicus
-
neutrophil pregnant women, G6PD translocates to microtubule-organizing centers Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?
additional information G6PD overexpressed in adipocytes in obese (including db/db, ob/ob and diet-induced obesity) mice, in adipocytes and stromal-vascular cells in diabetic db/db mice, and in adipocytes cultured under high-glucose conditions in vitro induces the expression of NADPH oxidase and leads to an increase in oxidative stress Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
G6PD
-
Mus musculus
G6PD
-
Homo sapiens
G6PD
-
Rattus norvegicus
G6PD
-
Saccharomyces cerevisiae
G6PD
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+ G6PD activity is regulated by the intracellular NADP+ levels and the NADPH/NADP+ ratio Homo sapiens