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Literature summary for 1.1.1.49 extracted from
- Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain (1990), Neuroscience, 38, 819-828.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens |  |
| ATP | - |
Sus scrofa | |
| EDTA | slightly | Homo sapiens | |
| EDTA | slightly | Sus scrofa | |
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Sus scrofa | |
| palmitoyl-CoA | leads to dissociation of active tetramers to inactive dimers | Homo sapiens | |
| palmitoyl-CoA | leads to dissociation of active tetramers to inactive dimers | Sus scrofa | |
| Zn2+ | - |
Homo sapiens | |
| Zn2+ | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | 0.008 | NADP+ | isoenzymes I and II, with glucose 6-phosphate | Homo sapiens | |
| 0.006 | 0.008 | NADP+ | isoenzymes I and II, with glucose 6-phosphate | Sus scrofa | |
| 0.023 | - |
NADPH | isoenzyme II, with 6-phosphonogluconate 0.1 mM | Sus scrofa | |
| 0.025 | - |
NADP+ | isoenzyme II, with 6-phosphonogluconate 0.1 mM | Homo sapiens | |
| 0.031 | - |
D-galactose 6-phosphate | isoenzyme II | Homo sapiens | |
| 0.046 | 0.047 | D-galactose 6-phosphate | isoenzyme I | Homo sapiens | |
| 0.046 | 0.047 | D-galactose 6-phosphate | isoenzyme I | Sus scrofa | |
| 0.051 | - |
D-galactose 6-phosphate | isoenzyme II | Sus scrofa | |
| 0.056 | - |
D-glucose 6-phosphate | isoenzyme II | Sus scrofa | |
| 0.061 | - |
D-glucose 6-phosphate | isoenzyme I | Homo sapiens | |
| 0.167 | - |
D-glucose 6-phosphate | isoenzyme I | Sus scrofa | |
| 0.18 | - |
D-glucose 6-phosphate | isoenzyme II | Homo sapiens | |
| 0.279 | - |
6-phosphonogluconate | isoenzyme II | Sus scrofa | |
| 0.864 | - |
6-phosphonogluconate | isoenzyme II | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation | Homo sapiens | |
| Ca2+ | activation | Sus scrofa | |
| Mg2+ | activation | Homo sapiens | |
| Mg2+ | activation | Sus scrofa | |
| additional information | no metal ions necessary | Homo sapiens | |
| additional information | no metal ions necessary | Sus scrofa |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
4 * 57000, SDS-PAGE | Homo sapiens |
| 57000 | - |
4 * 57000, SDS-PAGE | Sus scrofa |
| 220000 | - |
isoenzymes I and II, gel filtration | Homo sapiens |
| 220000 | - |
isoenzymes I and II, gel filtration | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate + H2O + NADP+ | Homo sapiens | - |
D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
| D-glucose 6-phosphate + H2O + NADP+ | Sus scrofa | - |
D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 isoenzymes | - |
| Sus scrofa | - |
2 isoenzymes | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isoenzymes I and II | Homo sapiens |
| isoenzymes I and II | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 50 | - |
purified isoenzyme I | Sus scrofa |
| 52 | - |
purified isoenzyme II | Homo sapiens |
| 201 | - |
purified isoenzyme II | Sus scrofa |
| 210 | - |
purified isoenzyme I | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phosphonogluconate + NADPH | isoenzyme II | Homo sapiens | ? | - |
? | |
| 6-phosphonogluconate + NADPH | isoenzyme II | Sus scrofa | ? | - |
? | |
| D-galactose 6-phosphate + NAD(P)+ | - |
Homo sapiens | D-galactonate 6-phosphate + NADH | - |
? | |
| D-galactose 6-phosphate + NAD(P)+ | - |
Sus scrofa | D-galactonate 6-phosphate + NADH | - |
? | |
| D-glucose 6-phosphate + H2O + NADP+ | - |
Homo sapiens | D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
| D-glucose 6-phosphate + H2O + NADP+ | - |
Sus scrofa | D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
| additional information | both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate | Homo sapiens | ? | - |
? | |
| additional information | both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate | Sus scrofa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 57000, SDS-PAGE | Homo sapiens |
| tetramer | 4 * 57000, SDS-PAGE | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | absolute specificity | Homo sapiens | |
| NADP+ | absolute specificity | Sus scrofa | |
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