Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-diphosphoglycerate | - |
Homo sapiens | |
NADP+ | at concentrations above 0.3 mM | Homo sapiens | |
NADPH | NADPH binding is important for physiological regulation of pentose phosphate pathway | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
NADP+ | with D-glucose 6-phosphate or D-galactose 6-phosphate | Homo sapiens | |
0.03 | - |
NADP+ | with 2-deoxyglucose 6-phosphate, KM decreases to 10 mM with increasing substrate concentration from 0.3 to 1.5 mM | Homo sapiens | |
0.04 | - |
D-glucose 6-phosphate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O + NADP+ | Homo sapiens | hyperbolic cofactor binding | D-gluconate 6-phosphate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | rapid equilibrium ordered bi bi kinetic | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
-10°C, 10 mM Tris-HCl, pH 7.4, 5 mM 2-mercaptoethanol, 2 mM EDTA, 40% glycerol (v/v), weeks | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-D-glucose-6-phosphate + NADP+ | - |
Homo sapiens | 2-deoxy-D-gluconate 6-phosphate + NADPH | - |
? | |
D-galactose 6-phosphate + NAD(P)+ | - |
Homo sapiens | D-galactonate 6-phosphate + NADH | - |
? | |
D-glucose 6-phosphate + deamino-NADP+ | - |
Homo sapiens | ? | - |
? | |
D-glucose 6-phosphate + H2O + NADP+ | hyperbolic cofactor binding | Homo sapiens | D-gluconate 6-phosphate + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
More | presence of SH-reagents, high enzyme and Mg2+ or Mn2+ concentrations, low pH and ionic strength favour oligomeric, active forms of the enzyme, while the opposite conditions favour inactive monomers | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
43 | - |
2-deoxyglucose 6-phosphate | - |
Homo sapiens | |
98 | - |
deamino-NADP+ | - |
Homo sapiens | |
157 | - |
D-galactose 6-phosphate | - |
Homo sapiens | |
571 | - |
D-glucose 6-phosphate | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
deamino-NADP+ | - |
Homo sapiens | |
NADP+ | high preference for | Homo sapiens |