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Literature summary for 1.1.1.45 extracted from

  • Goode, D.; Lewis, M.E.; Crabbe, M.J.C.
    Accumulation of xylitol in the mammalian lens is realted to glucoronate metabolism (1996), FEBS Lett., 395, 174-178.
    View publication on PubMed

Application

Application Comment Organism
medicine role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms Rattus norvegicus
medicine role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000 70000 HPLC gel filtration Rattus norvegicus
60000 70000 HPLC gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-gulonic acid + NAD+ Rattus norvegicus glucuronate-xylulose cycle 3-dehydro-L-gulonic acid + NADH + H+
-
?
L-gulonic acid + NAD+ Bos taurus glucuronate-xylulose cycle 3-dehydro-L-gulonic acid + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
rat
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-
lens
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-gulonic acid + NAD+
-
Rattus norvegicus 3-dehydro-L-gulonic acid + NADH + H+
-
r
L-gulonic acid + NAD+
-
Bos taurus 3-dehydro-L-gulonic acid + NADH + H+
-
r
L-gulonic acid + NAD+ glucuronate-xylulose cycle Rattus norvegicus 3-dehydro-L-gulonic acid + NADH + H+
-
?
L-gulonic acid + NAD+ glucuronate-xylulose cycle Bos taurus 3-dehydro-L-gulonic acid + NADH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NAD+
-
Bos taurus
NADH
-
Rattus norvegicus
NADH
-
Bos taurus