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Literature summary for 1.1.1.42 extracted from

  • Prasad, U.V.; Swarupa, V.; Yeswanth, S.; Kumar, P.S.; Kumar, E.S.; Reddy, K.M.; Kumar, Y.N.; Rani, V.J.; Chaudhary, A.; Sarma, P.V.
    Structural and functional analysis of Staphylococcus aureus NADP-dependent IDH and its comparison with bacterial and human NADP-dependent IDH (2014), Bioinformation, 10, 81-86.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence analysis Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures analysis using PDB IDs 1T09 and 1T0L Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O75874
-
-
Staphylococcus aureus D7RIE8
-
-
Staphylococcus aureus ATCC 12600 D7RIE8
-
-

Subunits

Subunits Comment Organism
More three-dimensional structure modelling, structure comparison with the enzyme from Staphylococcus aureus, overview Homo sapiens
More three-dimensional structure modelling, structure comparison with the human enzyme, PDB IDs 1T09 and 1T0L, overview Staphylococcus aureus

Synonyms

Synonyms Comment Organism
NADP-dependent IDH
-
Homo sapiens
NADP-dependent IDH
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADP+
-
Staphylococcus aureus

General Information

General Information Comment Organism
additional information three-dimensional structure modelling, isocitrate substrate docking, overview Homo sapiens
additional information three-dimensional structure modelling, isocitrate substrate docking, overview Staphylococcus aureus
physiological function the enzyme dictates the flow of carbon as part of the Krebs cycle thereby controlling the virulence and biofilm formation Homo sapiens
physiological function the enzyme dictates the flow of carbon as part of the Krebs cycle thereby controlling the virulence and biofilm formation Staphylococcus aureus