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Literature summary for 1.1.1.42 extracted from

  • Alvarado, A.; Flores, M.E.
    Characterization and regulation of NADP+-isocitrate dehydrogenase from Saccharopolyspora erythraea (2003), Biotechnol. Lett., 25, 1175-1178.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate 60% inhibition at 1 mM Saccharopolyspora erythraea
ADP 20% inhibition at 1 mM Saccharopolyspora erythraea
ATP 50% inhibition at 1 mM Saccharopolyspora erythraea
Citric acid 50% inhibition at 1 mM Saccharopolyspora erythraea
glyoxalate 20% inhibition at 1 mM, presence of 1 mM oxaloacetate results in 50% inhibition Saccharopolyspora erythraea
GTP 10% inhibition at 1 mM Saccharopolyspora erythraea
additional information no inhibition by phosphoenolpyruvate, fructose 1,6-bisphosphate, and pyruvate Saccharopolyspora erythraea
oxaloacetate 25% inhibition at 1 mM, presence of 1 mM glyoxalate results in 50% inhibition Saccharopolyspora erythraea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000028
-
NADP+ pH 7.5, 30°C Saccharopolyspora erythraea
0.00013
-
DL-isocitrate pH 7.5, 30°C Saccharopolyspora erythraea

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement for divalent cations Saccharopolyspora erythraea
Mn2+ requirement for divalent cations, preferred metal ion Saccharopolyspora erythraea

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
2 * 60000, SDS-PAGE Saccharopolyspora erythraea
130000
-
native PAGE Saccharopolyspora erythraea

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea
-
CA340
-
Saccharopolyspora erythraea CA340
-
CA340
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information growth-associated specific activity profile, dextrose or fructose are preferred before lactose as sole carbon source Saccharopolyspora erythraea
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity in cell free enzyme extracts of cells grown on diffeent carbon sources Saccharopolyspora erythraea
0.75
-
cell free enzyme extracts of cells grown on glucose, best carbon source Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-isocitrate + NADP+
-
Saccharopolyspora erythraea 2-oxoglutarate + CO2 + NADPH
-
?
DL-isocitrate + NADP+
-
Saccharopolyspora erythraea CA340 2-oxoglutarate + CO2 + NADPH
-
?

Subunits

Subunits Comment Organism
dimer 2 * 60000, SDS-PAGE Saccharopolyspora erythraea

Synonyms

Synonyms Comment Organism
ICDH
-
Saccharopolyspora erythraea
NADP+-isocitrate dehydrogenase
-
Saccharopolyspora erythraea

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Saccharopolyspora erythraea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Saccharopolyspora erythraea

Cofactor

Cofactor Comment Organism Structure
NADP+ preferred cofactor Saccharopolyspora erythraea