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Literature summary for 1.1.1.42 extracted from

  • Novotny, J.F.; Perry, J.J.
    Characterization of a heat-stable NADP-dependent isocitrate dehydrogenase from the obligate thermophile Thermoleophilum minutum YS-4 (1991), Appl. Microbiol. Biotechnol., 35, 461-465.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate
-
Thermoleophilum minutum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033
-
D,L-isocitrate
-
Thermoleophilum minutum
0.048
-
NADP+
-
Thermoleophilum minutum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cations Thermoleophilum minutum
Mn2+ absolute requirement for divalent cations Thermoleophilum minutum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30500
-
alpha2, 2 * 30500, SDS-PAGE Thermoleophilum minutum
60000
-
PAGE and gel filtration Thermoleophilum minutum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Thermoleophilum minutum
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+ Thermoleophilum minutum YS-4
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

Organism UniProt Comment Textmining
Thermoleophilum minutum
-
YS-4
-
Thermoleophilum minutum YS-4
-
YS-4
-

Purification (Commentary)

Purification (Comment) Organism
-
Thermoleophilum minutum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3884
-
-
Thermoleophilum minutum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Thermoleophilum minutum 2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+
-
Thermoleophilum minutum YS-4 2-oxoglutarate + NADPH + H+ + CO2
-
?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 30500, SDS-PAGE Thermoleophilum minutum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
75
-
-
Thermoleophilum minutum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
after 1 h incubation retains 57% of initial activity Thermoleophilum minutum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Thermoleophilum minutum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Thermoleophilum minutum