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Literature summary for 1.1.1.42 extracted from

  • Muro-Pastor, M.I.; Florencio, F.J.
    Purification and properties of NADP-isocitrate dehydrogenase from the unicellular cyanobacterium Synechocystis sp. PCC 6803 (1992), Eur. J. Biochem., 203, 99-105.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate non-competitive inhibitor Synechocystis sp.
5'-ADP non-competitive inhibitor Synechocystis sp.
NADPH competitive inhibitor Synechocystis sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
Mn2+ Mn2+-dependent reaction Synechocystis sp.
0.0057
-
D,L-isocitrate Mn2+-dependent reaction Synechocystis sp.
0.006
-
NADP+ Mn2+-dependent raction Synechocystis sp.
0.012
-
NADP+ Mg2+-dependent reaction Synechocystis sp.
0.059
-
D,L-isocitrate Mg2+-dependent reaction Synechocystis sp.
0.125
-
Mg2+ Mg2+-dependent reaction Synechocystis sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cations Synechocystis sp.
Mn2+ absolute requirement for divalent cations Synechocystis sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
alpha2, 2 * 57000, SDS-PAGE Synechocystis sp.
108000
-
gel filtration Synechocystis sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Synechocystis sp.
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

Organism UniProt Comment Textmining
Synechocystis sp.
-
PCC 6803
-

Purification (Commentary)

Purification (Comment) Organism
-
Synechocystis sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
15.7
-
-
Synechocystis sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Synechocystis sp. 2-oxoglutarate + NADPH + H+ + CO2
-
?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 57000, SDS-PAGE Synechocystis sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Synechocystis sp.

pH Range

pH Minimum pH Maximum Comment Organism
7.5 10
-
Synechocystis sp.

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Synechocystis sp.