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Literature summary for 1.1.1.41 extracted from

  • Alvarez-Villafane, E.; Soler, J.; del Valle, P.; Busto, F.; de Arriaga, D.
    Two NAD+-dependent isocitrate dehydrogenase forms in Phycomyces blakesleeanus. Induction in response to acetate growth and characterization, kinetics, and regulation of both enzyme forms (1996), Biochemistry, 35, 4741-4752.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AMP activates ICDH-1 Phycomyces blakesleeanus

General Stability

General Stability Organism
ICDH-2 is more stable to urea than ICDH-1 Phycomyces blakesleeanus

Inhibitors

Inhibitors Comment Organism Structure
NADH inhibits ICDH-2 Phycomyces blakesleeanus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, active substrate is Mg-DL-isocitrate chelate Phycomyces blakesleeanus
Mn2+ requires divalent cations Phycomyces blakesleeanus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40500
-
alpha8, 8 * 40500, SDS PAGE, ICDH-1 and ICDH-2 Phycomyces blakesleeanus
338000
-
gel filtration Phycomyces blakesleeanus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Phycomyces blakesleeanus
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Phycomyces blakesleeanus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Phycomyces blakesleeanus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
37.5
-
ICDH-1 Phycomyces blakesleeanus
48.9
-
ICDH-2 Phycomyces blakesleeanus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Phycomyces blakesleeanus 2-oxoglutarate + CO2 + NADH + H+
-
?

Subunits

Subunits Comment Organism
octamer alpha8, 8 * 40500, SDS PAGE, ICDH-1 and ICDH-2 Phycomyces blakesleeanus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30 60
-
Phycomyces blakesleeanus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9
-
Phycomyces blakesleeanus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Phycomyces blakesleeanus