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Literature summary for 1.1.1.40 extracted from

  • Hsieh, J.Y.; Liu, G.Y.; Hung, H.C.
    Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346 (2008), FEBS J., 275, 5383-5392.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ATP
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0053
-
NADP+ in 50 mM Tris-HCl (pH 7.4) Homo sapiens
18.6
-
NAD+ in 50 mM Tris-HCl (pH 7.4) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Homo sapiens pyruvate + CO2 + NADH
-
?
(S)-malate + NADP+
-
Homo sapiens pyruvate + CO2 + NADPH
-
?
(S)-malate + NADP+ weak reaction Homo sapiens pyruvate + CO2 + NADPH
-
?

Synonyms

Synonyms Comment Organism
c-NADP-ME
-
Homo sapiens
cytosolic NADP+-dependent malic enzyme
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
34.18
-
NAD+ in 50 mM Tris-HCl (pH 7.4) Homo sapiens
113.2
-
NADP+ in 50 mM Tris-HCl (pH 7.4) Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+ preferred cofactor Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.77
-
ATP in the presence of NAD+, in 50 mM Tris-HCl (pH 7.4) Homo sapiens
5.91
-
ATP in the presence of NADP+, in 50 mM Tris-HCl (pH 7.4) Homo sapiens