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Literature summary for 1.1.1.399 extracted from

  • Gharbia, S.; Shah, H.
    Isolation, purification and characterisation of 2-oxoglutarate reductase from Fusobacterium nucleatum (1991), FEMS Microbiol. Lett., 80, 283-288.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dipyridyl disulfide
-
Fusobacterium nucleatum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000004
-
NADH at pH 7.5 and 25°C Fusobacterium nucleatum
0.000064
-
2-oxoglutarate at pH 7.5 and 25°C Fusobacterium nucleatum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000, SDS-PAGE Fusobacterium nucleatum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-2-hydroxyglutarate + NAD+ Fusobacterium nucleatum
-
2-oxoglutarate + NADH + H+
-
r
2-oxoglutarate + NADH + H+ Fusobacterium nucleatum
-
(R)-2-hydroxyglutarate + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Fusobacterium nucleatum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sepharose-4B-(glutathione-2-pyridyl disulfide) column chromatography Fusobacterium nucleatum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-hydroxyglutarate + NAD+
-
Fusobacterium nucleatum 2-oxoglutarate + NADH + H+
-
r
2-oxoglutarate + NADH + H+
-
Fusobacterium nucleatum (R)-2-hydroxyglutarate + NAD+
-
r
additional information no activity with oxaloacetate, pyruvate, 2-oxobutyrate and glyoxylate Fusobacterium nucleatum ?
-
?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Fusobacterium nucleatum

Synonyms

Synonyms Comment Organism
serA
-
Fusobacterium nucleatum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45 60 the enzyme is stable at 45°C for 10 min, 70% of its activity is lost at 50°C, 5% of the original activity is retained at 55°C, while incubation at 60°C abolishes all activity Fusobacterium nucleatum

Cofactor

Cofactor Comment Organism Structure
NADH the enzyme is almost entirely specific towards NADH Fusobacterium nucleatum