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Literature summary for 1.1.1.39 extracted from

  • Hsieh, J.Y.; Chen, M.C.; Hung, H.C.
    Determinants of nucleotide-binding selectivity of malic enzyme (2011), PLoS ONE, 6, e25312.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K362H the mutant enzyme displays a considerable elevation in Km for NADP+, and the kcat for NAD+ value is elevated compared to the wild-type enzyme Ascaris suum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Ascaris suum 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Ascaris suum
-
pyruvate + CO2 + NADH
-
r

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Ascaris suum pyruvate + CO2 + NADH
-
r

Synonyms

Synonyms Comment Organism
m-NAD-ME
-
Ascaris suum

Cofactor

Cofactor Comment Organism Structure
NAD+ His362 is involved in NAD+-specific catalysis of NAD-ME, and residue 314 may interact with the bisphosphate of the NAD+ moiety, structure analysis, overview Ascaris suum