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Literature summary for 1.1.1.39 extracted from

  • Chang, H.C.; Chen, L.Y.; Lu, Y.H.; Li, M.Y.; Chen, Y.H.; Lin, C.H.; Chang, G.G.
    Metal ions stabilize a dimeric molten globule state between the open and closed forms of malic enzyme (2007), Biophys. J., 93, 3977-3988.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Urea denaturation, in 3-5 M urea, the enzyme undergoes a reversible tetramer-dimer-monomer quaternary structural change in an acidic pH environment, which resulted in a molten globule state that is prone to aggregate, Mn2+ protects, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ during the catalytic process of malic enzyme, binding of metal ion induces a conformational change within the enzyme from the open form to an intermediate form, which upon binding of L-malate, transforms further into a catalytically competent closed form Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Homo sapiens
-
pyruvate + CO2 + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Homo sapiens pyruvate + CO2 + NADH
-
r

Subunits

Subunits Comment Organism
tetramer structure analysis from crystal structure, the enzyme is a tetrameric protein with double dimer quaternary structure, pH dependence of enzyme structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
mitochondrial NAD+-dependent malic enzyme
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
enzyme conformation at different pH values, overview Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens