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Literature summary for 1.1.1.39 extracted from

  • Mitsch, M.J.; Cowie, A.; Finan, T.M.
    Malic Enzyme Cofactor and Domain Requirements for Symbiotic N2-fixation by Sinorhizobium meliloti (2006), J. Bacteriol., 189, 160-168.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information expression of the tme gene, EC 1.1.1.40, under the control of the dme promoter, cannot restore the N2 fixation activity which is lost in dme mutant cells in alfalfa root nodules, despite elevated levels of TME within bacteroids, no symbiotic nitrogen fixation occurs in dme mutant strains, overview Sinorhizobium meliloti

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Sinorhizobium meliloti the enzyme plays a role in symbiotic N2 fixation, overview pyruvate + CO2 + NADH
-
r

Organism

Organism UniProt Comment Textmining
Sinorhizobium meliloti
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bacteroid the level of the enzyme in wild-type bacteroids is not limiting for N2-fixation Sinorhizobium meliloti
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Sinorhizobium meliloti pyruvate + CO2 + NADH
-
r
(S)-malate + NAD+ the enzyme plays a role in symbiotic N2 fixation, overview Sinorhizobium meliloti pyruvate + CO2 + NADH
-
r

Synonyms

Synonyms Comment Organism
diphosphate nucleotide dependent malic enzyme
-
Sinorhizobium meliloti
DME
-
Sinorhizobium meliloti
NAD+-dependent malic enzyme
-
Sinorhizobium meliloti

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sinorhizobium meliloti
NADH
-
Sinorhizobium meliloti