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Literature summary for 1.1.1.37 extracted from

  • Leroux, A.; Fleming-Canepa, X.; Aranda, A.; Maugeri, D.; Cazzulo, J.J.; Sanchez, M.A.; Nowicki, C.
    Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp (2006), Mol. Biochem. Parasitol., 149, 74-85.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
mitochondrial, glycosomal and cytosolic isoforms are expressed in Escherichia coli Leishmania major

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
oxaloacetate cytosolic isoenzyme Leishmania major
0.031
-
oxaloacetate cytosolic isoenzyme Leishmania mexicana
0.041
-
NADH mitochondrial isoenzyme Leishmania major
0.056
-
oxaloacetate mitochondrial isoenzyme Leishmania major
0.057
-
NADH cytosolic isoenzyme Leishmania mexicana
0.057
-
oxaloacetate glycosomal isoenzyme Leishmania major
0.061
-
NADH glycosomal isoenzyme Leishmania major
0.066
-
NADH cytosolic isoenzyme Leishmania major
0.069
-
NAD+ cytosolic isoenzyme Leishmania major
0.121
-
NAD+ mitochondrial isoenzyme Leishmania major
0.252
-
NAD+ glycosomal isoenzyme Leishmania major
1.007
-
(S)-malate glycosomal isoenzyme Leishmania major
3.3
-
(S)-malate cytosolic isoenzyme Leishmania major
15
-
(S)-malate mitochondrial isoenzyme Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Leishmania major 5829
-
cytosol
-
Leishmania mexicana 5829
-
glycosome
-
Leishmania major 20015
-
mitochondrion
-
Leishmania major 5739
-

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-
Leishmania mexicana Q0QW09
-
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
Leishmania major
-
promastigote
-
Leishmania mexicana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Leishmania major oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH + H+
-
Leishmania mexicana (S)-malate + NAD+
-
?

Subunits

Subunits Comment Organism
? x * 32000-34000, SDS-PAGE Leishmania major
? x * 32000-34000, SDS-PAGE Leishmania mexicana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 8.5 reduction of oxaloacetate, cytosolioc enzyme Leishmania major
6.5
-
reduction of oxaloacetate, glycosomal enzyme Leishmania major
9
-
reduction of oxaloacetate, mitochondrial enzyme Leishmania major