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Literature summary for 1.1.1.37 extracted from

  • Aranda, A.; Maugeri, D.; Uttaro, A.D.; Opperdoes, F.; Cazzulo, J.J.; Nowicki, C.
    The malate dehydrogenase isoforms from Trypanosoma brucei: subcellular localization and differential expression in bloodstream and procyclic forms (2006), Int. J. Parasitol., 36, 295-307.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
mitochondrial and glycosomal malate dehydrogenase isoenzyme, functional expression in Escherichia coli Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
oxaloacetate glycosomal enzyme Trypanosoma brucei
0.036
-
NADH glycosomal enzyme Trypanosoma brucei
0.054
-
NADH pH 7.5, 37°C, glycosomal enzyme Trypanosoma brucei
0.069
-
oxaloacetate glycosomal enzyme Trypanosoma brucei
0.085
-
NADH pH 7.5, 37°C, glycosomal enzyme Trypanosoma brucei
0.32
-
NADH glacosomal enzyme Trypanosoma brucei
0.56
-
(S)-malate pH 7.5, 37°C, mitochondrial enzyme Trypanosoma brucei
2.7
-
p-hydroxyphenylpyruvate
-
Trypanosoma brucei
2.72
-
(S)-malate pH 7.5, 37°C, glycosomal enzyme Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic isoenzyme is the only isoform of malate dehydrogenase expressed in the bloodstream form Trypanosoma brucei 5829
-
glycosome
-
Trypanosoma brucei 20015
-
mitochondrion
-
Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Trypanosoma brucei mitochondrial enzyme, Krebs cycle oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH Trypanosoma brucei cytosolic enzyme and glycosomal enzyme (S)-malate + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei O15769
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bloodstream form the cytosolic isoenzyme is the only isoform of malate dehydrogenase expressed in the bloodstream form Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+ mitochondrial enzyme, Krebs cycle Trypanosoma brucei oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH cytosolic enzyme and glycosomal enzyme Trypanosoma brucei (S)-malate + NAD+
-
r
oxaloacetate + NADH + H+
-
Trypanosoma brucei (S)-malate + NAD+
-
r
p-hydroxyphenylpyruvate + NADH + H+
-
Trypanosoma brucei 2-hydroxy-3-(4-hydroxyphenyl)propanoate
-
?
phenylpyruvate + NADH + H+
-
Trypanosoma brucei 2-hydroxy-3-phenylpropanoate + NAD+
-
?